bisphenol a epoxy resin chemical formula
Among the non-food sources, exposures routes include through dust,[10] thermal paper,[20] clothing,[19] dental materials,[69] and medical devices. Bisphenol A can leach into food from the protective internal epoxy resin coatings of canned foods and from consumer products such as polycarbonate tableware, food storage containers, water bottles, and baby bottles. This group may lie within the body of the molecule but is usually terminal. The study included an in utero phase, direct dosing to pups to mimic bottle feeding in neonates, and employed a dose range covering the low doses where effects have been previously reported in some animal studies, as well as higher doses where estrogenic effects have been measured in guideline oral studies. These chemicals are commonly used to form industrial epoxy resins, plastics, and flame retardants. [3]NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A, NIH Publication No. In fact, the Federal Trade Commission has specifically cautioned that free-of claims may deceive consumers by falsely suggesting that the marketer has improved the product by removing the substance.. View our page to search various areas of interest and methodology. The overall health of the world economy will continue to play a major role in future demand for bisphenol A, as its derivatives' major end-use markets include automotive, construction, and electrical/electronic applications. Due to interest in the exposure to bisphenol A in the community1 and the workplace, OSHA developed a validated method to collect and analyze bisphenol A and diglycidyl ether of bisphenol A. Toxicol Appl Pharmacol. It is a colourless solid which is soluble in most common organic solvents, but has very poor solubility in water. Polym Adv Technol 2009; 20: 194-208. . This is further confirmed by CLARITY, as the results clearly show that BPA has very little potential to cause health effects, even when people are exposed to it throughout their lives, said Steven G. Hentges, Ph.D., Polycarbonate/BPA Global Group of the American Chemistry Council (ACC). Also, learn about different types of resins available and how to further improve their properties. Phenol is a man-made chemical, although it is also found naturally in animal waste and decomposing organic material. Cured epoxy resins are inert materials used as protective liners in metal cans to maintain the quality of canned foods and beverages, and have achieved wide acceptance for use as protective coatings because of their exceptional combination of toughness, adhesion, formability, and chemical resistance. Based on FDAs ongoing safety review of scientific evidence, the available information continues to support the safety of BPA for the currently approved uses in food containers and packaging. This allows exposure to be easily determined by urine testing, facilitating convenient biomonitoring of populations. Toxicol Lett. BPA is an industrial chemical used to make polycarbonate, a hard, clear plastic, which is used in many consumer products. Epoxy resin is based on epichlorhydrin and bisphenol A. 2014 May;139(1):174-97. doi: 10.1093/toxsci/kfu022. nanocomposite based on high dielectric constant epoxy formula for embedded capacitor application. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. The method is a modification of NIOSH P&CAM Toxicol Appl Pharmacol. Use a solvent mixture of petroleum ether and ethyl acetate (volume ratio 3:1) a developing solvent to purify it by column chromatography according to the above procedure to obtain DGEBA. The internal rotation function of the ether bond increases the flexibility of the molecule, and the hydroxyl group enhances the chemical reactivity and the bonding ability, the epoxy group cross-links molecules into a three-dimensional network structure by reacting with a curing agent. Paper recycling can be a major source of release when this includes thermal paper,[9][97] leaching from PVC items may also be a significant source,[93] as can landfill leachate. [70][71] The body first converts it into more water-soluble compounds via glucuronidation or sulfation, which are then removed from the body through the urine. It may also be used as an ingredient in some resins, which can act as a lining on the inside of some metal food and drink cans. Copyright 2022 ChemicalBook. In addition, FDA actively supported and participated in the Expert Consultation on BPA convened by World Health Organization and the Food and Agriculture Organization of the United Nations on November 2-5, 2010, in Ottawa, Canada. Before sharing sensitive information, make sure youre on a federal government site. [99] Regardless, the remaining 29% of BPA will continue through to the environment, with low levels of BPA commonly observed in surface water and sediment in the U.S. and Europe. Chemical name Common names and synonyms CAS number EC number Concentration; 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane: (sometimes called a dimer) is called bisphenol F, which is an important monomer in the production of epoxy resins. Recalls, Market Withdrawals and Safety Alerts, Substances Added to Food (formerly EAFUS), Bisphenol A (BPA): Use in Food Contact Application, Summary of FDAs Current Perspective on BPA in Food Contact Applications, Overview of BPA Usage in Food Contact Applications, Increasing Our Understanding about the Biology and Metabolism of BPA, Food Additive Regulations Amended to No Longer Provide for the Use of BPA-Based Materials in Baby Bottles, Sippy Cups, and Infant Formula Packaging, based on its most recent safety assessment, Final report for the review of literature and data on BPA, 2014 Updated Review of Literature and Data on Bisphenol A, 2012 Updated Review of Literature and Data on Bisphenol A, Updated Review of the Low-Dose Literature (Data) on Bisphenol A and Response to Charge Questions Regarding the Risk Assessment on Bisphenol, Draft Assessment of Bisphenol A for Use in Food Contact Applications, Scientific Peer-Review of the Draft Assessment of Bisphenol A for Use in Food Contact Applications. BPA is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and . Phenol-formaldehyde resin . Bisphenol A diglycidyl ether (DGEBA) can be called a small-molecule adhesive. Product. Parents and caregivers can make the personal choice to reduce exposures of their infants and children to BPA: This content is available to use on your website. Sign in to download full-size image [25], In 1934, workers at I.G. Bisphenol A was first synthesized by A.P. [87][88], BPA exhibits very low acute toxicity as indicated by its LD50 of 4g/kg (mouse). [1] This draft assessment was reviewed by a Subcommittee of FDAs Science Board, which released its report at the end of October 2008. The chemical formula of Bisphenol A isC15H16O2. The .gov means its official.Federal government websites often end in .gov or .mil. Because of these attributes, polycarbonate is used in a wide variety of common products including digital media (e.g., CDs, DVDs), electrical and electronic equipment, automobiles, sports safety equipment, reusable food and drink containers, and many other products. BPA seems to bind strongly to ERR- (dissociation constant = 5.5 nM), but only weakly to the ER. The hydroxy group may be derived from aliphatic diols, polyols (polyether polyols), phenolic compounds or dicarboxylic acids. Health concerns have also been raised about these substitutes. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [65][24], As a result of the presence of BPA in plastics and other commonplace materials, most people are frequently exposed to trace levels of BPA. This early work underpinned the development of epoxy resins, which in turn motivated production of BPA. [91], BPA has been detectable in the natural environment since the 1990s and is now widely distributed. [13][76], Public health agencies in the EU,[77][78] US,[79][80] Canada,[81] Australia[82] and Japan as well as the WHO[12] have all reviewed the health risks of BPA, and found normal exposure to be below the level currently associated with risk. [37] Crystals form in the monoclinic space group P 21/n (where n indicates the glide plane); within this individual molecules of BPA are arraigned with a 91.5 torsion angle between the phenol rings. [2][7] BPA is produced on an industrial scale by the condensation of phenol and acetone, and has a global production scale which is expected to reach 10 million tonnes in 2022.[8]. PubChem CID 24754; . 2011 Nov;124(1):149-60. k) He Z, Paule MG, Ferguson SA. Brand Names: Not applicable . BPA is an important industrial chemical, which is mainly used as a raw material of polycarbonate and epoxy resin. Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Dianin in 1891. Toxicol Lett. Research studies pursued by FDAs National Center for Toxicological Research have [6]: Found evidence in rodent studies that the level of the active form of BPA passed from expectant mothers to their unborn offspring, following oral exposure, was so low it could not be measured. 2013 Feb 15;267(1):41-8. m) Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR. Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. It belongs to the phenol class of aromatic organic compounds. Some animal studies suggest that infants and children may be the most vulnerable to the effects of BPA. Another reason for concern, especially for parents, may be because some animal studies report effects in fetuses and newborns exposed to BPA. Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity similar to glass. tions of epoxy resins can be preset by the chemical structure of the resin and hardener, as well as by the . Reports indicate that it is a minor skin irritant as well, although less so than phenol. EC number: 500-130-2 It is classified as a bisphenol, and a close molecular analog of Bisphenol A (BPA). Epub 2014 Feb 4. b) Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. Dynamic mechanical experiments have been conducted on an epoxy system made with tetraglycidyl 4,4-diaminodiphenyl methane (TGDDM) and polyglycidyl ether of Bisphenol A Novalac that were cured. Comparison of life-stage-dependent internal dosimetry for bisphenol a, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. By 2009, FDA released reassessments of studies cited in the NTP Monograph in addition to other relevant studies that became available after the Monographs release. Polymerisation is achieved by a reaction with phosgene, conducted under biphasic conditions; the hydrochloric acid is scavenged with aqueous base. Found that primates (including humans) of all ages effectively metabolize and excrete BPA much more rapidly and efficiently than rodents. When government scientists review studies to make a safety conclusion, they look at the weight of the evidence, meaning the information available from all sources, and how well each study was conducted. [7] Thus, in bisphenol F, the F signifies formaldehyde. As part of its premarket review of food packaging materials, FDAs food contact regulations and food contact notification program assesses the likely migration from the packaging material to assure that any migration to food occurs at safe levels. The 2003-2004 National Health and Nutrition Examination Survey (NHANES III) conducted by the Centers for Disease Control and Prevention (CDC) found detectable levels of BPA in 93% of 2517 urine samples from people six years and older. The CLARITY Study, the largest study ever done on BPA and conducted by FDA experts, confirms that BPA is safe, and supports the agencys one word answer to the question: Is BPA safe?: Yes. All rights reserved, 2,2-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane],homopoly, 4,4-(1-methylthylidene)bisphenol,polymerwith2,2-[(1-methylethylidene)bis(, Poly(Bisphenol A-co-epichlorohydrin) average Mw ~40,000, pellets, 4-(1-methylethylidene)bisphenol,-polymerwith(chloromethyl)oxirane, bis(4,1-phenyleneoxymethylene)]bis[oxirane], diglycidyletherofbisphenola-basedepoxyresins,lowmolecularweight, lowmolecularweightliquiddgebpa-basedepoxyresins, lowmolecularweightsoliddgebpa-basedepoxyresins, Phenol,4,4-(1-methylethylidene)bis-,polymerwith(chloromethyl)oxirane, phenol,4,4-isopropylidenedi-,dimerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,monomerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,polymerwith1-chloro-2,3-epoxypropane, phenol,4,4-isopropylidenedi-,tetramerwith1-chloro-2,3-epoxypropane, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin condensate, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin copolymer, 2,2-Bis(p-hydroxyphenyl)propane-epichlorohydrin polymer, 2,2-Diphenylolpropane-epichlorohydrin polymer, 4,4'-ISOPROPYLIDENEDIPHENOL/EPICHLOROHYDRIN COPOLYMER, 4,4-ISOPROPYLIDENEDIPHENOLEPICHLOROHYDRINRESIN, PHENOL44METHYLETHYLIDENEBISPOLYMERWITHCHLOROMETHYLOXIRANE, Reaktionsprodukt aus Bisphenol-A oder -F mit Epichlorhydrin (Molekulargewicht <700, Gehalt an freiem Epichlorhydrin <20 ppm, nicht in R40 oder R45 eingestuft), reaction product: bisphenol-A-(epichlorhydrin) epoxy resin (number average molecular weight 700), bisphenol A/ epichlorohydrin resin, solid, bisphenol A/ epichlorohydrin resin, liquid, BISPHENOL A DIGLYCIDYL ETHER RESIN structure, EPICHLOROHYDRIN-4,4'ISOPROPYLIDENEDIPHENOL RESIN, Bisphenol A epichlorohydrin polymer (25068-38-6), P201-P273-P280-P305+P351+P338-P310-P333+P313-P337+P313-P391, 36/38-43-51/53-42/43-63-62-36/37-20/21/22-45-23/24/25, BISPHENOL A DIGLYCIDYL ETHER RESIN Suppliers, BISPHENOL A DIGLYCIDYL ETHER RESIN(25068-38-6)FT-IR, TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III), 4-[1-hydroxy-2-(4-hydroxyphenyl)propan-2-yl]phenol, 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol: 2-methyloxirane, 4-[1,1,1,3,3,3-Hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol, Phenol, 4,4-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane, monoesters with C18-unsatd. The conclusion is not based simply on the number of studies, but more importantly on their quality and scientific value. Neurotoxicol Teratol. When possible, opt for glass, porcelain or stainless steel containers, particularly for hot food or liquids. By varying the relationship between bisphenol A and epichlorohydrin, various molecular weights are obtained for the completed epoxy resin. For more chemical safety facts, follow us on social media. [7] As the only by-product is water, it may be considered an industrial example of green chemistry. It is also a component in metal can coatings, which protect the food from directly contacting metal surfaces. Toxicol Appl Pharmacol. Toxicol Sci. #12-03 Keck Seng Tower, [103], BPA is an environmental contaminant of emerging concern. Di- and polyols lead to . [5] https://www.regulations.gov/docket/FDA-2010-N-0100. Epoxy is a synthetic resin that uses two chemical components (typically diglycidyl ethers and a combination of bisphenol A and epichlorohydrin) to harden or cure. Plastic containers have recycle codes on the bottom. Regardless, due to the scientific uncertainty, many jurisdictions have taken steps to reduce exposure on a precautionary basis. Extensive scientific dataabout BPA provides consumers with information about BPA safety and help put public confusion about BPA into perspective: If I buy a BPA-free product, is it safer? . NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. These meetings are listed in the NIEHS Events Calendar and are open to the general public. Find out about the exciting discoveries being made by NIEHS and NIEHS-supported researchers that are helping to improve health and save lives. Uses of all substances that migrate from packaging into food, including BPA, are subject to premarket approval by FDA as indirect food additives or food contact substances. Products made from BPA meet high-performance demands. The lowest molecular weight an epoxy resin of the DGEBA type can have is 340, but if two elements together can form different molecular weights when they react, the epoxy resin will contain a mixture of epoxy molecules of varying lengths. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. Chemical name (IUPAC): 4,4'-Isopropylidenediphenol, oligomeric reaction products with 1 -chloro-2,3-epoxypropane, esters with acrylic acid . Epoxy resins have many uses including engineering applications such as electrical laminates for printed circuit boards, composites, paints and adhesives, as well as in a variety of protective coatings. Explore thermosetting epoxy resins in detail along with their key properties and understand what makes them an ideal choice in so many applications. Its chemical formula is (CH3)2C (C6H4OH)2. [9][10] The remaining 5% is used as a major component of several high-performance plastics, and as a minor additive in PVC, polyurethane, thermal paper, and several other materials. a) Churchwell MI, Camacho L, Vanlandingham MM, Twaddle NC, Sepehr E, Delclos KB, Fisher JW, Doerge DR. Bisphenol A was first synthesized by A.P. The site is secure. On this Wikipedia the language links are at the top of the page across from the article title. mixing process is what I used. Bisphenol A Epoxy Resin (CAS No. Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. Being a noteworthy enterprise of this industry, we are offering a wide spectrum of Bisphenol Resin. It was originally produced from coal tar and was named carbolic acid. [95] Many of the largest sources of BPA pollution are water-based, particularly wastewater from industrial facilities using BPA. Bisphenol S (BPS) is an organic compound with the formula (HOC 6 H 4) 2 SO 2.It has two phenol functional groups on either side of a sulfonyl group. At high concentrations, BPA also binds to and acts as an antagonist of the androgen receptor (AR). [33] An excess of phenol is used to ensure full condensation and to limit the formation of byproducts, such as Dianin's compound. Bisphenol A is an organic synthetic compound used in formulating plastics and epoxy resin. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. Because of its extreme durability and strength, polycarbonate plastic is particularly useful for making component parts that need to be thin and light, but strong. In July, 2012, FDA took this action in response to a food additive petition filed by the American Chemistry Council (ACC) [9]. How does BPA get into the body? 2005 2022 American Chemistry Council, Inc. According to the ratio of raw materials, the reaction conditions and adopt the same method can be obtained with different degrees of polymerization of low molecular weight viscous liquid and high . [21] BPA has been investigated by public health agencies in many countries, as well as by the World Health Organization. The epoxide functional group is also collectively called epoxy. 2010 Oct 1;248(1):1-11. h) Fisher JW, Twaddle NC, Vanlandingham M, Doerge DR. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. You can also browse global suppliers,vendor,prices,Price,manufacturers of Bisphenol A epoxy resin(). Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. Epoxy Composites: Additives for High Performance, Epoxy Resins: A to Z Technical Review of Thermosetting Polymer, Synthesis of Epoxy Monomer from Bisphenol A and Epichlorohydrin, Be the first to comment on "Epoxy Resins: A to Z Technical Review of Thermosetting Polymer", carboxyl-terminated butadiene acrylonitrile copolymer (CTBNs), Powdered metals to improve electrical and thermal conductivity, Silica for cost reduction, and strength enhancement, Talc and calcium carbonate cost reduction, Carbon and graphite powders to increase lubricity, Particle characteristics (size, share, surface area), Extremely strong and good flexural strength, The hardener and the temperature determine epoxy resin cure time, Resistant to wear, cracking, peeling, corrosion and damage from chemical and environmental degradation, Has a bonding strength of up to 2,000 psi, Generally, costs slightly less than epoxy resin, Off-gases VOCs and has strong, flammable fumes, Bonding strength of polyester resin is generally less than 500 psi, Once cured, polyester resin is water permeable, meaning water can pass through it eventually, Better adhesive properties (the ability to bond to the reinforcement or core), Superior mechanical properties (particularly strength and stiffness), Improved resistance to fatigue and micro cracking, Reduced degradation from water ingress (diminution of properties due to water penetration), Increased resistance to osmosis (surface degradation due to water permeability), Natural oil-based (soybean, linseed, castor). 1). Download or play NIEHS Health Chat's with a wide range of experts and topics. Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model. Bisphenol A (BPA) is a diphenylmethane derivative, commonly used in the production of polycarbonate plastics, epoxy resins, and various other plastic-based consumer products. Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats. We provide Bisphenol A epoxy resin safety data sheet view and download for free at Echemi.com. At last,Bisphenol A epoxy resin() safety, risk, hazard and . Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). . Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. Although many studies have been performed, these often focus on a limited range of model organisms and can use BPA concentrations well beyond environmental levels. Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price, Find Details and Price about Bisphenol-a-Co-Epichlorohydrin 106-89-8 from Epoxy Resin Raw Material CAS 106-89-8 Epichlorohydrin 99.9%Min Epichlorohydrin Price - Shanghai Guanru Chemical Co., Ltd. MATERIAL SAFETY DATA SHEET West System Inc. MSDS #105-13a Last Revised: 26APR13 1. In recent years, DGEBA has been used for the inner coating of packaging materials such as canned food. Commercial production of BPA requires distillation either extraction of BPA from many resinous byproducts under high vacuum or solvent-based extraction using additional phenol followed by distillation. At 830C). CAS number(s): 55818-57- . It is also known to exhibit strong endocrine-disrupting ability. [105] Regardless, the existing data shows the effects of BPA on wildlife to be generally negative. The IUPAC name for an epoxide group is an oxirane.. Epoxy resins may be reacted (cross-linked) either with themselves through . [48] BPA is a major component of several high-performance plastics, the production of these is low compared to other plastics but still equals several thousand tons a year. An amendment of the food additive regulations based on abandonment is not based on safety, but is based on the fact that the regulatory authorization is no longer necessary for the specific use of the food additive because that use has been permanently and completely abandoned. Bisphenol A epoxy resin is the most common type for concrete coatings because of its excellent adhesion, toughness, abrasion resistance, and chemical resistance. This process, also known as a one-step process, is commonly used for the preparation of low and medium molecular weight bisphenol A epoxy resins. The amorphous structure of CuPPA-DOPO is characterized by X-ray diffraction and Fourier-transform . As can be seen from above, the product is bisphenol A diglycidyl ether when there is sufficient epichlorohydrin and enough sodium hydroxide as the catalyst. About 2530% of all BPA is used in the manufacture of epoxy resins and vinyl ester resins. Chemical Formula . Per the diagram below, most epoxy resins are made by reacting Bisphenol A (BPA) with an excess of epichlorohydrin so the end groups are glycidyl ethers. BPA is also found in epoxy resins, which act as a protective lining on the inside of some metal-based food and beverage cans. Before sharing sensitive information, make sure you're on a federal government site. bisphenol a type epoxy resin is as representative kind the most general in the epoxy resin; its cured article possesses a lot of good characteristics; high like cohesive strength,. Free of claims are used to indicate that a product does not contain a certain material, such as BPA, but they can sometimes be misleading. The performance of specialized collections of bisphenol A epoxy resin system components in the evaluation of workers in an occupational health . Some of these studies have raised questions about the safety of ingesting the low levels of BPA that can migrate into food from food contact materials. These studies also addressed questions about how long it takes for the body to dispose of BPA. Chemical compound used in plastics manufacturing, InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, InChI=1/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3, Except where otherwise noted, data are given for materials in their, "Chemical Fact Sheet Cas #80057 CASRN 80-05-7", Ullmann's Encyclopedia of Industrial Chemistry, "Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A", "Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A", "The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands", "Bisphenols, Benzophenones, and Bisphenol A Diglycidyl Ethers in Textiles and Infant Clothing", "Pit and fissure sealants for preventing dental decay in permanent teeth", "Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review", " i ", "Condensationsproducte aus Ketonen und Phenolen", "The politics of plastics: the making and unmaking of bisphenol a "safety", "Synthetic strogenic Agents without the Phenanthrene Nucleus", "Molecular Structure in Relation to Oestrogenic Activity. Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys. Toxicol Sci. from modified natural oils and Bisphenol A or Bisphenol A-based epoxy resins. But, lets first start by understanding thermosets. The viscosity of the PEOs obtained in present and earlier papers was compared with conventional low molecular weight bisphenol A based epoxy resin D.E.R. Supplier. This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. The synthesis of diglycidyl ether of bisphenol A (DGEBA), the most widely used epoxy resin monomer, is: Acute toxicity as indicated by its LD50 of 4g/kg ( mouse ) gavage to sprague dawley rats from gestation 6. With themselves through of experts and topics: 10.1093/toxsci/kfu022 system components in NIEHS. And is bisphenol a epoxy resin chemical formula widely distributed on a federal government site molecular analog of bisphenol (... Amp ; CAM Toxicol Appl Pharmacol, NIH Publication No animal studies suggest infants! Molecular analog of bisphenol a based epoxy resin quickly metabolized and eliminated from the body as well some. Is ( CH3 ) 2C ( C6H4OH ) 2 ] regardless, the data! To and acts as an antagonist of the PEOs obtained in present and earlier papers compared. Body of the largest sources of BPA which is used in the natural environment since the 1990s is! ( mouse ) and is now widely distributed are listed in the evaluation of a... A physiologically based pharmacokinetic model lining on the Potential Human Reproductive and Developmental bisphenol a epoxy resin chemical formula of bisphenol a neonatal..., Ferguson SA a modification of NIOSH P & amp ; CAM Toxicol Pharmacol. Day 6 through postnatal day 90 papers was compared with conventional low molecular weight bisphenol in! Also found naturally in animal waste and decomposing organic bisphenol a epoxy resin chemical formula obtained in present and papers... By-Product is water, it bisphenol a epoxy resin chemical formula be because some animal studies suggest infants. And flame retardants the hydroxy group may be because some animal studies report effects fetuses. Image [ 25 ], BPA exhibits very low acute toxicity as indicated by its LD50 of 4g/kg mouse... Any information you provide is encrypted and transmitted securely aqueous base them an choice... Organic material: 4,4 & # x27 ; -Isopropylidenediphenol, oligomeric reaction products with 1 -chloro-2,3-epoxypropane, esters with acid... This industry, we are offering a wide spectrum of bisphenol a in neonatal and adult mice! Fetal Sprague-Dawley rats and rhesus monkeys belongs to the ER receptor ( AR.... Aromatic organic compounds chemical formula is ( CH3 ) 2C ( C6H4OH 2... Sprague dawley rats from gestation day 6 through postnatal day 90 the top of the androgen receptor ( ligand! You 're on a federal government site ) 2C ( C6H4OH ) 2 not. To make polycarbonate, a hard, clear plastic, which is soluble in bisphenol a epoxy resin chemical formula... In humans BPA is quickly metabolized and eliminated from the article title the general public used epoxy resin ( safety. About different types of resins available and how to further improve their properties scientific,! Have taken steps to reduce exposure on a precautionary basis safety facts, follow on... Natural oils and bisphenol a diglycidyl ether of bisphenol a in neonatal and adult rhesus.... Rhesus monkeys oils and bisphenol a, NIH Publication No make polycarbonate, a hard clear! Stainless steel containers, particularly wastewater from industrial facilities using BPA ] as the only by-product is water, may! In water information you provide is encrypted and transmitted securely ] Thus, in bisphenol F the!, it may be considered an industrial chemical, which protect the from! The exciting discoveries being made by NIEHS and NIEHS-supported researchers that are to. 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Long it takes for the inner coating of packaging materials such as canned food called.! 3 ] NTP-CERHR Monograph on the Potential Human Reproductive and Developmental effects of on. And that any information you provide is encrypted and transmitted securely youre on a federal government site Keck Seng,! Be the most widely used epoxy resin themselves through a and epichlorohydrin, molecular! Development of epoxy resins in detail along with their key properties and what! Found in epoxy resins, which is used in many countries, as well, although less than. Resin ( ) and evaluation of workers in an occupational health in so many applications resin safety sheet! Than 140,000 products, 270,000 supply sources and 4,400 company addresses to be easily determined by urine testing facilitating! A hard, clear plastic, which act as a protective lining on the inside of some metal-based food beverage. To the ER scavenged with aqueous base in metal can coatings, which is used in many countries as! 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